CT Air Trapping Is Independently Associated with Lung Function Reduction over Time

نویسندگان

  • Onno M. Mets
  • Pim A. de Jong
  • Bram van Ginneken
  • Cas L. J. J. Kruitwagen
  • Mathias Prokop
  • Matthijs Oudkerk
  • Jan-Willem J. Lammers
  • Pieter Zanen
چکیده

PURPOSE We aimed to study the association between lung function decline and quantitative computed tomography (CT) air trapping. MATERIALS AND METHODS Current and former heavy smokers in a lung cancer screening trial underwent volumetric low-dose CT in inspiration and expiration. Spirometry was obtained at baseline and after 3 years. The expiratory to inspiratory ratio of mean lung density (E/I-ratioMLD) was used to quantify air trapping. CT emphysema was defined as voxels in inspiratory CT below -950 Hounsfield Unit. Linear mixed modeling was used to determine the association between CT air trapping and lung function. RESULTS We included 985 subjects with a mean age of 61.3 years. Independent of CT emphysema, CT air trapping was significantly associated with a reduction in forced expiratory volume in one second (FEV1) and the ratio of FEV1 over the forced vital capacity (FEV1/FVC); FEV1 declines with 33 mL per percent increase in CT air trapping, while FEV1/FVC declines 0.58% per percent increase (both p<0.001). CT air trapping further elicits accelerated loss of FEV1/FVC (additional 0.24% reduction per percent increase; p = 0.014). CONCLUSION In a lung cancer screening cohort, quantitatively assessed air trapping on low-dose CT is independently associated with reduced lung function and accelerated decline of FEV1/FVC.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2013